Synthesis of New Organoselenium Compounds Containing Nucleosides as Antioxidant
نویسندگان
چکیده
Selenium containing nucleosides derived from some heterocyclic moieties such as Pyridineselenol, and pyridazineselenol is described herein. Ribosylation of selenol compounds were prepared in good yield by silyation of selenol derivatives with 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose followed by debenzoylation to afford the corresponding free N-nucleosides and -1-(2,3,5-trihydroxy--D-ribofuranosyl)-2-seleno-4,6-dimethylpyridine-3-carbonitrile (6a,7a); b and a-1-(2,3,5-trihydroxy--D-ribofuranosyl)-3-seleno-5,6-diphenylpyridazine-4-carbonitrile (6b,7b). Newly synthesized compounds were characterized using the well known spectroscopic tools (IR, 1HNMR, 13CNMR and mass spectroscopy). Antioxidant activity of six selenonucleoside compounds (1a; 6a; 7a; 1b; 6b and 7b) was evaluated by animal assay model using experimental mice. The resulted data revealed that compounds 6a and 7b showed to be more active as antioxidant with a better performance of scavenging ability than the other compounds.
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